The Mandarin Oriental Hotel Group signed a deal with Blumenthal?s The Fat Duck Group last year.
The two have worked with designer Adam Tihany to create the 140-cover restaurant, called Dinner by Heston Blumenthal.
Blumenthal said: "I am thrilled at the prospect of opening a restaurant in such a central London location. Working in partnership with a hotel group is a natural step and one which offers an exciting opportunity."